An antibiotic called works to prevent as well as treat several bacterial infections, like respiratory tract infections, meningitis, urinary tract infections, salmonellosis, and endocarditis. It can be given for preventing group B streptococcal infection in newborns. It can be given by injection into a muscle, or intravenously, or used by mouth. It is not recommended for the viral infections treatment.
Here are some common side effects of Ampicillin Capsules BP:
Serious side effect of Ampicillin Capsules BP is Clostridium difficile colitis or anaphylaxis.
Note: It must not be indicated to people allergic to penicillin. The dose must be decreased in people with kidney problems. It is safe to use during pregnancy and breatfeeding.
In the year 1961 when Ampicillin was developed, it was regarded as the most important medications required in a basic health system on the list of Essential Medicines by the World Health Organization.
It works well against several Gram-positive and Gram-negative bacteria.
Ampicillin was the first used against Gram-positive bacteria such as Streptococcus pyogenes, Streptococcus pneumoniae, some Enterococcus, some isolates of Staphylococcus aureus (but not penicillin-resistant or methicillin-resistant strains). It is also effective against Gram-negative bacteria including some Haemophilus influenzae, some Enterobacteriaceae and Neisseria meningitidis. When administered with sulbactam, it's spectrum is enhanced.
Many bacterial infections can be treated with its use, including some common respiratory infections like sinusitis, pharyngitis and bronchitis, as well as otitis media. When given with vancomycin, it can treat bacterial meningitis. It is also recommended for the treatment of gastrointestinal infections due to the consumption of contaminated water or food, like Shigella, Salmonella and Listeria.
Ampicillin is a first-line agent for treating infections due to enterococci. It is because of bacteria, several healthcare-associated infections like meningitis, endocarditis and catheter-associated urinary tract infections resistant to other antibiotics are developed.
- Molar mass: 349.406 g/mol
- IUPAC ID: (2S,5R,6R)-6-([(2R)-2-amino-2-phenylacetyl]amino) -3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2- carboxylic acid
- Formula: C16H19N3O4S
- CAS ID: 69-53-4
- Trade name: Principen, others
- Metabolism: 12 to 50%
- Elimination half-life: Approx. 1 hour